Van de Ven Double Halts Everton's Run at Brand New Home Ground
The Dutch defender became the first defender to score twice in a English top-flight match for Spurs since Jan Vertonghen in spring 2013.
Match summary
The Spurs defender heads home twice in first half
Everton's Jake O'Brien has goal ruled after VAR review
Senegalese midfielder scores final goal in dying moments
This loss is the Merseyside club's first at their new ground
The Tottenham defender found the net twice as Tottenham prolonged their winning streak in away games in the top division and delivered Everton their first defeat at Hill Dickinson Stadium.
Everton were unbeaten in their five previous fixtures at their new ground at Bramley-Moore Dock, having departed their historic home behind after more than a century at the conclusion of last season.
But Spurs captain Van de Ven struck on two occasions from set-pieces in the first half to put their impressive record at risk, and they were failed to turn it around before Pape Matar Sarr - set up by former Toffees attacker the Brazilian - headed home a third to seal the victory.
The Everton defender thought he had levelled the scores five minutes after the defender's opener, directing a bullet header past Guglielmo Vicario from an set-piece.
The Portuguese striker, in the meantime, failed to convert a number of opportunities, while the Italian goalkeeper made a series of excellent saves to ensure Tottenham went five away games without defeat in the Premier League.
But the VAR stepped in, advising the match official to check the goal on the pitchside monitor and the referee decided that the winger and Iliman Ndiaye were in an illegal position and had impeded with the Spurs keeper.
This victory elevates the manager's team up to third in the Premier League, a handful of points off north London rivals and leaders Arsenal.
Everton stay in 14th position and are half a dozen points clear of the relegation zone.
Tottenham analysis: The defender excels in role at each end of pitch
Following a uninspiring midweek display in the European competition against Monaco, where they mustered a only two shots on goal, Frank chose the French striker up front instead of ex-Everton forward the Brazilian.
The summer signing was unable to influence the game before being replaced for Richarlison after 60 minutes on the pitch, but it emerged he wasn't needed in the end.
Defender the Dutchman transformed into an offensive threat to be reckoned with.
Tottenham's opening strike came from a cleverly executed set-piece play, with Rodrigo Bentancur heading the ball toward the face of goal for an free the defender to head home.
And Ven de Ven - stepping up as captain in the Argentine's absence - notched his next goal in first-half stoppage time as he outjumped Jordan Pickford to head home.
The Dutchman was equally outstanding in defensive duties, partnering effectively with his defensive colleague as the duo dealt excellently with the numerous deliveries thrown their way by Everton.
Everton analysis: Everton lacking finishing touch
Everton's recent stadium had been a fortress, but it seems the freshness may have worn off somewhat and fans headed to the gates after the midfielder's third for Spurs.
The break in Everton's unbeaten home run will not be a major worry for David Moyes, but their striker situation are.
Beto and the other striker - the Everton's pair of established strikers - had netted just a single goal between them before Sunday's match.
And they were failed to add to that poor tally on a damp and dreary evening on Merseyside.
The striker's form was epitomized when he opted to bicycle-kick a golden opportunity from near the goal, despite having room and time to readjust for a more conventional shot that would have tested the keeper.
The substitute, too, failed to make an impact after coming on for Beto in the 65th minute.
It was not for a shortage of chance. Most of Everton's attacks came through the winger and the forward, who tirelessly whipped dangerous crosses into the Spurs penalty area.
What next for both teams?
The Toffees: Moyes' men travel to Sunderland in the top flight on Monday, 3 November at 8 PM.
Spurs: The London club go to St James' Park on Wednesday, 29 October for their next round League Cup tie against Newcastle.